Abstract
The reaction has been studied spectrophotometrically; the reaction shows two steps, both of which are dependent on ligand concentration and show a limiting nature. An associative interchange mechanism is proposed. Kinetic and activation parameters ( and ) and (, , , and ) have been calculated. From the temperature dependence of the outer sphere association equilibrium constant, thermodynamic parameters ( and ; and ) have also been calculated.
Highlights
The binding of the antitumor drug cisplatin and other platinum group metal complexes, especially ruthenium(II), rhodium(III), iridium(III), platinum(II), and palladium(II) to amino acids, nucleosides, nucleotides, and to DNA is still an interesting subject and has given considerable impetus to research in the area of metal ion interactions with nucleic acid constituents
Ruthenium complexes are an order of magnitude less toxic than cisplatin, and aqua complexes if used directly will be less toxic as some hydrolyzed side products are responsible for toxicity
In this paper, we have studied the kinetic details of the interaction of our chosen complex (an aqua-amine complex of ruthenium(II)) with an S-containing amino acid DL-methionine at pH 7.4 in aqueous medium and a plausible mechanism is proposed
Summary
The binding of the antitumor drug cisplatin and other platinum group metal complexes, especially ruthenium(II), rhodium(III), iridium(III), platinum(II), and palladium(II) to amino acids, nucleosides, nucleotides, and to DNA is still an interesting subject and has given considerable impetus to research in the area of metal ion interactions with nucleic acid constituents. From a literature survey [1,2,3], it is revealed that many potential alternative metallopharmaceuticals have been developed, ruthenium being one of the most promising, and are currently undergoing clinical trials [4,5,6,7] Another point of interest is that DNA is not the only target. RNA [8,9,10] and several sulphur donor ligands, present in the blood, are available for kinetic and thermodynamic competition [11, 12] Keeping this in mind, in this paper, we have studied the kinetic details of the interaction of our chosen complex (an aqua-amine complex of ruthenium(II)) with an S-containing amino acid DL-methionine at pH 7.4 in aqueous medium and a plausible mechanism is proposed
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