Abstract
Kinetics of oxidation of Levamisole hydrochloride (LVM) by sodium N-bromo-p-toluene sulfonamide or bromamine-T (BAT) in presence of HCl has been investigated at 303K. The Stoichiometry of the reaction was found to be 1:1 and the oxidation product of levamisole hydrochloride was identified as Levamisole S-oxide was characterized by GC-MS analysis. The rate of reaction shows first-order dependence on (BAT)0, (LVM)0 and fractional-order dependence with (H + )0. Effects of added p- toluene sulfonamide (PTS) and halide ions, varying ionic strength (NaClO4) and dielectric constant of the medium on the rate of reaction have been investigated. Activation parameters were calculated and the reaction constants involved in the mechanisms have been computed. The proposed mechanisms and the derived rate laws are consistent with the observed kinetics. Keywords: Kinetics, Levamisole hydrochloride, oxidation, bromamine-T, mechanism.
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