Abstract
Blood concentrations of cyanide, lactate, glucose, oxypurines and allantoin were determined in rats sampled at 10 min after the intraperitoneal administration of various concentrations of potassium cyanide. Lactate and oxypurines in plasma increased biquadratically with increase in the cyanide concentration in blood. The concentrations of cyanide for half maximal effect were 1.63 μg/ml for lactate and 2.09 μg/ml for oxypurines. Plasma glucose increased quadratically with increase in the cyanide concentration, and the marked increase was observed where plasma lactate concentration became near maximal. Plasma allantoin concentrations were not significantly changed throughout the experiments. The present results indicate that determination of plasma oxypurines as well as lactate is an excellent parameter for tissue hypoxia.
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