Abstract
The conductance of the pore formed by the bacterial toxin aerolysin shows complex modulation in the presence of a single blocking molecule, such as an oligonucleotide or a peptide, that can be attributed to the stochastic oscillation of the analyte molecule between two energy minima inside the pore. For adenine oligonucleotides, the statistics of these oscillations conform with a simple kinetic model where these minima are linked by voltage-dependent rate constants and correspond to two binding sites arranged sequentially along the pore's transmembrane axis.
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