Abstract
Purpose
 To study the peculiarities of adaptive and compensatory reactions in mature women after prolonged hypokinesia using various kinesiological models of the neuromuscular system readaptation.
 Material and methods
 52 women of mature age (39-46 years) after long-term (6-7 years) hypokinesia took part in the study. Group A used a kinesiological model based on free weight exercises with changes in kinematic and dynamic characteristics. Group B used a model based on machine exercises. The following methods were used to monitor adaptation processes: bioelectrical impedance analysis, anthropometry, testing of strength capabilities, biochemical blood analysis (cortisol and creatinine concentration).
 Results 
 The dynamics of the studied indicators differed significantly between the groups using the proposed kinesiological models for 12 weeks. Thus, the fat-free and body cell mass indicators were 5 times higher in group A women compared to group B participants. The body fat mass decreased by 5 times in group A participants. The circumference measurements reduced in all participants, but in group A the rate of change was 1.8 times faster. The level of strength growth was almost the same in all study participants; it fluctuated within 10-25% compared to the initial data. The cortisol concentration in the blood serum increased only in group B during all stages of control. At the end of the research, the cortisol level did not change in response to stress in the women of group A, which indicates increasing of their resistance level. The basal level of creatinine grew by 4% in group A women after 12 weeks of training, but it did not change in group B participants. These changes indicate an accelerated growth of muscle mass in group A women.
 Conclusions
 Pronounced adaptive changes occurred in women of mature age after prolonged hypokinesia in case of using the kinesiological model of the neuromuscular system readaptation with free weight exercises. Applying this model helps to increase the functional capabilities of the body, to strengthen the level of resistance to a stress stimulus, and to improve the morphometric parameters of the body.
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