Kinerja Fungsi Ginjal pada Kelinci (Lepus nigricollins) Diabetes yang diberi Ekstrak Bonggol Buah Nanas (Ananas comusus L.)

Abstract

Bromelain enzyme contained in pineapple ( Ananas comosus L.) are enzyme that have a function as anti-inflamatory in diabetic treatment periodically, will be giving impact to kidney function performance. This study to determine the effect of pineapple hump extract ( Ananas comosus L.) on creatinine level in diabetic rabbits. Rabbits were acclimated for 3 weeks than measured the creatinine level to know the first level. So, it induced by alloxan as much as 195 mg/kg during ±2 weeks for conditioning under hyperglicemia. Then measured the creatinine level from 6 groups, it given pineapple extract with different concentration, those are positive control (+), negative control (-), extract 25%, 50%, 75% and 100%. Then measured of creatinine level did in enzymatic photometric method. In group of concentration 25% the creatinine level from 0,58 mg/dl become 1,07 mg/dl, in concentration 50% from 1,55 mg/dl become 1,25 mg/dl, in concentration 75% from 1,63 mg/dl become 1,19 mg/dl and in concentration 100% from 1,58 mg/dl become 1,42 mg/dl. The result of the study were tested statiscally with one way Anova test, it showed p> 0,05. It show Pineapple hump extract has no effect on the role of diabetic rabbits kidney.