Abstract
Mycoplasma synoviae and Mycoplasma hyopneumoniae are wall-less eubacteria belonging to the class of Mollicutes. These prokaryotes have a reduced genome size and reduced biosynthetic machinery. They cause great losses in animal production. M. synoviae is responsible for an upper respiratory tract disease of chickens and turkeys. M. hyopneumoniae is the causative agent of enzootic pneumonia in pigs. The complete genomes of these organisms showed 17 ORFs encoding kinases in M. synoviae and 15 in each of the M. hyopneumoniae strain. Four kinase genes were restricted to the avian pathogen while three were specific to the pig pathogen when compared to each other. All deduced kinases found in the non pathogenic strain (J[ATCC25934]) were also found in the pathogenic M. hyopneumoniae strain. The enzymes were classified in nine families composing five fold groups.
Highlights
Edmond Nocard and Emile Roux successfully cultivated the agent of the contagious bovine pleuropneumonia, Mycoplasma mycoides, over a century ago (Nocard and Roux, 1898)
The amino acid sequence relationships were generated with the predicted protein sequences obtained from 47 kinase-encoding Open Reading Frames (ORF) identified in the complete genome sequences of M. synoviae and M. hyopneumoniae
In this study we briefly review the kinase genes of M. hyopneumoniae and M. synoviae, and we describe a classification and metabolic comparative analysis of kinases of these organisms
Summary
Edmond Nocard and Emile Roux successfully cultivated the agent of the contagious bovine pleuropneumonia, Mycoplasma mycoides, over a century ago (Nocard and Roux, 1898). These and other 102 species comprise the class of Mollicutes (Minion et al, 2004) These prokaryotes are known as the smallest self replicating organisms (Glass et al, 2000; Westberg et al, 2004). The complete genomes of a pathogenic (7448) and nonpathogenic (J [ATCC 25934]) strains of Mycoplasma hyopneumoniae, as well as the complete genome of a strain (53) of Mycoplasma synoviae (Vasconcelos et al, 2005) were obtained Both species cause great adverse impact on animal production. Complete genome sequencing identified 679, 681 and 694 Open Reading Frames (ORF) of M. hyopneumoniae strains J (Mhy-J), 7448 (Mhy-P) and M. synoviae strain 53 (Msy), respectively Analysis of these mycoplasma genomes by bioinformatics tools identified 15 Mhy-J ORFs, 15 Mhy-P ORFs and 17 Msy ORFs, all of which encode kinases. Due to the biological importance of these enzymes we expect that their study will improve the comprehension of the reduced biosynthetic pathways in mollicutes
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