Kimura's Disease: An Inflammatory Disorder Mimicking a Parotid Mass

Abstract

the diagnosis and management of Kimura’s disease, which often presents as a mass in the head and neck. To describe the histopathological and laboratory findings in patients with Kimura’s disease and understand the treatment recommendations. Objective: Eosinophilic hyperplastic lymphogranuloma, more commonly known as Kimura’s disease, is an inflammatory disorder most frequently found in middle-aged Asian men. It has a predilection for the head and neck region and presents with its own set of clinical characteristics and histologic features. The clinical findings, surgical management, and pathologic description of a patient with Kimura’s disease are presented. Study design: case report and literature review. Methods: The patient’s clinical records were examined for history, laboratory values, biopsy results, operative procedure, and pathologic diagnosis. A literature review for Kimura’s disease was also performed in PUBMED. Results: A fifty-two-year-old Chinese man presented with a left preauricular mass, which initially appeared to be of parotid origin. Laboratory values demonstrated eosinophilia, and fineneedle aspiration biopsy showed clusters of epithelioid histiocytes, lymphocytes, and foamy macrophages. He underwent surgical excision without complication. Pathologic examination demonstrated Kimura’s disease. Conclusion: Although rare, Kimura’s disease has been reported in the literature originating from countries in Asia since 1937. Surgical excision is the treatment of choice, followed by steroid and/or other immunosuppressive therapy. As the population seeking medical care becomes more diverse, it is important for the otolaryngologist to include Kimura’s disease in formulating the differential diagnosis of head and neck masses. KIMURA’S DISEASE: AN INFLAMMATORY DISORDER MIMICKING A PAROTID MASS David Hu, MD1; Sheeja T. Pullarkat, MD2; Brit Shackley, MD2; Marilene B. Wang, MD1 1Division of Head and Neck Surgery, 2Department of Pathology and Laboratory Medicine; David Geffen School of Medicine at UCLA, Los Angeles, CA