Kimura Disease: A Case Report and Literature Review

Abstract

Background:Kimura disease (KD) is a chronic and benign inflammatory disease and the etiology is still unknown. KD is rare and primarily seen in young Asian males. It is usually presented as painless subcutaneous masses or regional lymphadenopathy over head and neck. Patients with KD may be transferred from other departments for cosmetic need with diverse non-specific complaints. For diagnostic imaging, ultrasonography and magnetic resonance imaging (MRI) reveal more characteristic findings than computed tomography (CT). However, histopathology is the most convincible method to prove the disease.Aim and objectives:We presented a patient with a tender palpable mass over posterior scalp from clinical symptoms, laboratory data, and images to the pathological findings and reviewed the details of KD from the literature.Materials and Methods:In this paper, we reported one female patient with KD which presented a tender palpable mass over posterior scalp. Her peripheral blood data including eosinophils count and renal function were normal.Results:The mass was excised completely and histopathological investigation revealed hyperplasia of germinal centers accompanied with capillaries proliferation and rich eosinophils infiltration. Thus KD was diagnosed according to the result of histopathology. The local tenderness subsided after the mass removal. The patient was regularly followed up for 2 years without recurrent symptoms.Conclusion:Although KD is a pathological diagnosed disease, we could still find some clues by blood laboratory data and image study. Surgery is the first choice of therapy, while other conservative management such as regional or systemic corticosteroid therapy, radiotherapy and medication therapy has also been reported. Although KD has a high recurrence rate, it is definitely a benign disease which must be differentiated from malignant neoplasms.