Abstract
In their recent publication in Science, Stenger et al.1 Stenger S. et al. Science. 1998; 282: 121-125 Crossref PubMed Scopus (872) Google Scholar describe a microbicidal molecule that provides cytolytic T lymphocytes (CTLs) with a potent weapon against bacterial, fungal and protozoal infections. This seminal finding helps to resolve a long-standing question: namely, whether CTLs participate directly in defence against intracellular microorganisms. The implications, however, are more far-reaching and are pertinent to novel therapeutic measures that are urgently required against multidrug-resistant (MDR) pathogens.
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