Abstract
Natural Killer Cells Recognition of evolutionarily conserved pathogen-associated molecules drives innate immune responses. Naiyer et al. report that a killer immunoglobulin receptor (KIR) called KIR2DS2 promotes activation of natural killer (NK) cells. KIR2DS2 recognizes conserved peptides from flaviviral RNA helicases when they are presented by a particular human leukocyte antigen (HLA) allele called HLA-C*0102. Two distinct peptide motifs are sensed by KIR2DS2: LNPSVAATL and MCHAT. The former is conserved across hepatitis C virus isolates; the latter is conserved in several flaviviruses, including dengue, Zika, and yellow fever. Hence, a single KIR receptor has evolved to activate NK cells in response to multiple pathogenic viruses. Sci. Immunol. 2 , eaal5296 (2017).
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
