Abstract

Objective To investigate the killing effect of cytokine-induced killer cell (CIK) mediated by bispecific single-chain antibody in vivo on colon cancer cells. Methods The colon cancer model in nude mice was established with SW1116 cells. The mice were divided into 3 groups, which were injected with normal saline, CIK cells and CIK cells + bispecific antibody, respectively, once a week for 4 weeks. The tumors were removed and weighed, and the tumore inhibition rate in each group was calculated. Results The CIK cells and CIK cells with bispecific single-chain antibody could both inhibit tumor growth in vivowith the tumor inhibition rate being 29. 70% and 65.02% respectively ( P < 0. 05 ). There was significant difference in tumor inhibition rate between CIK cells and CIK cells with bispecific single-chain antibody ( P < 0. 05 ). Conclusion CIK cells alone can inhibit tumor cell growth, CIK cells in combination with bispecific single-chain antibody can exert more significant antitumor effect. Key words: Colon carcinoma; CIK cells; Bispecific single chain antibody

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