Abstract
Methods Between 1995 and 2006, 566 HIV-1 serodiscordant couples in Zambia, were followed for counseling and serologic testing for a minimum of nine months. KIR genes and HLA alleles were detected by standard typing methods. We tested the association of KIR genes and KIR gene/HLA ligand combinations with HIV-1 transmission and with index partner viral load (VL). All analyses of VL by linear regression were adjusted for age, sex, and time from enrollment. Covariates in proportional hazards models of HIV-1 transmission included VL in all index partners and genital ulcers in all partners.
Highlights
Killer immunoglobulin-like receptor (KIR) genes regulate natural killer cell function
We investigated the impact of KIR and KIR/HLA genes on heterosexual transmission in an African cohort
We tested the association of KIR genes and KIR gene/HLA ligand combinations with HIV-1 transmission and with index partner viral load (VL)
Summary
Killer immunoglobulin-like receptor (KIR) genes regulate natural killer cell function. KIR gene content has been reported to influence HIV-1 acquisition and progression, but consensus is lacking. We investigated the impact of KIR and KIR/HLA genes on heterosexual transmission in an African cohort
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