Abstract
Background Hepatocellular carcinoma (HCC) lacks effective treatments and has a poor prognosis. Therefore it is needed to develop more effective drug targets. Kinesin family member 11 (KIF11) has been reported to affect the progression of several cancers, and its high expression associates with the prognosis of patients. However, the relevant mechanisms of KIF11 in HCC progression have not been studied. Method Through the cancer genome atlas (TCGA) database and immunohistochemical (IHC) staining of patients' specimens, we determined that KIF11 was highly expressed in HCC tissues and associated with prognosis. We established a KIF11 stably depleted hepatoma cell line, through cell-cloning experiments and cell counting kit-8 (CCK-8) assays to detect the effects on proliferation in vitro. The role of KIF11 in promoting cell proliferation was verified in mice. Result The expression of KIF11 was negatively correlated with the overall survival (OS) and disease-free survival (DFS) and positively correlated with tumor size of HCC patients. KIF11 depletion inhibits cell proliferation and tumor growth in vitro and in vivo. Conclusion. KIF11 can be used as a positive correlation marker for HCC prognosis and served as a potential therapeutic target.
Highlights
Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer and the second most common cause of cancer death worldwide, especially in South Africa and East Asia [1,2,3,4,5,6]
We revealed the expression of Kinesin family member 11 (KIF11) in hepatocellular carcinoma through analyzing the cancer genome atlas (TCGA) database and IHC staining of patient specimens
KIF11 Is Associated with the Poor Prognosis of HCC Patients
Summary
Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer and the second most common cause of cancer death worldwide, especially in South Africa and East Asia [1,2,3,4,5,6]. The prognosis of HCC patients was still poor. Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic malignancies and is the most common form of primary liver cancer [11, 12]. Hepatocellular carcinoma (HCC) lacks effective treatments and has a poor prognosis. Kinesin family member 11 (KIF11) has been reported to affect the progression of several cancers, and its high expression associates with the prognosis of patients. Through the cancer genome atlas (TCGA) database and immunohistochemical (IHC) staining of patients’ specimens, we determined that KIF11 was highly expressed in HCC tissues and associated with prognosis. The expression of KIF11 was negatively correlated with the overall survival (OS) and disease-free survival (DFS) and positively correlated with tumor size of HCC patients. KIF11 can be used as a positive correlation marker for HCC prognosis and served as a potential therapeutic target
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