Kidney Transplantation From Elderly Donors: A Prospective Randomized Study Comparing Celsior and UW Solutions

Abstract

Aim The aim of present study was to assess the effect of Celsior as compared with University of Wisconsin (UW) solution on immediate and long-term function of kidney transplants harvested from elderly donors. Methods A prospective multicenter randomized study was designed to evaluate the efficacy of Celsior versus UW solution for the clinical preservation of the kidney. Fifty renal transplants were performed from donors over 60 years old. Twenty-five kidneys were stored in Celsior and 25 in UW solution. The groups were comparable with regard to donor and recipient characteristics. Renal function outcomes were compared by evaluating delayed graft function rates, daily urinary output, as well as the evolution of mean serum creatinine at 1, 3, 5, 7, and 15 days. Results The warm ischemia time was 42.4 ± 11 minutes among Celsior vs 46.9 ± 17.9 minutes in the UW cohort ( P = NS). The cold ischemia time was 18 ± 4.5 hours in Celsior and 19 ± 6.5 hours in UW ( P = NS). Delayed graft function occurred in 48% of the Celsior group and in 52% of the UW group ( P = NS). Mean serum creatinine levels and mean daily urinary output were also similar. One- and 5-year graft survivals of kidneys preserved with Celsior were 91.8% and 79.3% compared with 96% and 87.4% for UW without any significant statistical difference. Conclusions Our data show that the preservation of kidneys from elderly donors in Celsior solution is equivalent to that of UW solution.