Abstract
Bone disease is a serious and common condition in patients after kidney transplantation. The review analyzed the causes of bone disorders in the early and late postoperative period that are associated with renal transplantation: fibroblast growth factor 23, parathyroid hormone, vitamin D, immunosuppressive therapy and imbalance of mineral metabolism. It shows the most common clinical variant of the post-transplant bone disease – secondary osteoporosis, risk factors of its development and complications. It presents the diagnostic algorithm for dynamic monitoring and evaluating the effectiveness of the treatment of bone disorders
Highlights
Заболевание костей является серьезной и часто встречающейся патологией у пациентов, перенесших трансплантацию почки
The review analyzed the causes of bone disorders in the early and late postoperative period that are associated with renal transplanta tion: fibroblast growth factor 23, parathyroid hormone, vitamin D, immunosuppressive therapy and imbalance of mineral metabolism
It shows the most common clinical variant of the post-transplant bone disease – secondary osteoporosis, risk factors of its development and complications. It presents the diagnostic algorithm for dynamic monitoring and evaluating the effectiveness of the treatment of bone disorders
Summary
ГБУЗ МО «Московский областной научно-исследовательский клинический институт имени М.Ф. The review analyzed the causes of bone disorders in the early and late postoperative period that are associated with renal transplanta tion: fibroblast growth factor 23, parathyroid hormone, vitamin D, immunosuppressive therapy and imbalance of mineral metabolism It shows the most common clinical variant of the post-transplant bone disease – secondary osteoporosis, risk factors of its development and complications. Общепризнано, что трансплантация почки явля ется наилучшим методом заместительной почечной терапии для достижения удовлетворительной ме дико-социальной реабилитации пациентов, страда ющих хронической болезнью почек (ХБП) 5-й ст., обеспечивающим им высокое качество и большую продолжительность жизни. Развитие костной патологии – посттрансплан тационная костная болезнь (ПТКБ) – является за кономерным осложнением ХБП, тесно связанным с угасанием почечных функций, что приводит к сложным гормонально-метаболическим нарушени ям, в том числе и костного метаболизма. Интерес специалистов многих стран к данной проблеме ве лик, об этом свидетельствуют публикации послед них лет [1,2,3,4,5,6]
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