Kidney Transplant Outcomes in the Super Obese: A National Study From the UNOS Dataset.

Abstract

We evaluated outcomes of super-obese patients (BMI>50) undergoing kidney transplantation in the US. We performed a review of 190 super-obese patients undergoing kidney transplantation from 1988 through 2013 using the UNOS dataset. Super-obese patients had a mean age of 45.7years (21-75years) and 111 (58.4%) were female. The mean BMI of the super-obese group was 56 (range 50.0-74.2). A subgroup analysis demonstrated that patients with BMI>50 had worse survival compared to any other BMI class. The 30-day perioperative mortality and length of stay was 3.7% and 10.09days compared to 0.8% and 7.34days in nonsuper-obese group. On multivariable analysis, BMI>50 was an independent predictor of 30-day mortality, with a 4.6-fold increased risk of perioperative death. BMI>50 increased the risk of delayed graft function and the length of stay by twofold. The multivariable analysis of survival showed a 78% increased risk of death in this group. Overall patient survival for super-obese transplant recipients at 1, 3, and 5years was 88, 82, and 76%, compared to 96, 91, 86% on patients transplanted with BMI<50. A propensity score adjusted analysis further demonstrates significant worse survival rates in super-obese patients undergoing kidney transplantation. Super-obese patients had prolonged LOS and worse DGF rates. Perioperative mortality was increased 4.6-fold compared to patients with BMI<50. In a subgroup analysis, super-obese patients who underwent kidney transplantation had significantly worse graft and patient survival compared to underweight, normal weight, and obesity class I, II, and III (BMI 40-50) patients.