Abstract
Hepatic injury can be induced by the administration of carbon tetrachloride (CCl4) via the production of free radicals. The present work was initiated to investigate the kidney response to hepatic injury induced by CCl4 and its treatment by L-arginine. Female Swiss albino mice were supplied with L-arginine for 6 days (orally, 200 mg/kg body weight) prior or post to hepatic injury induction through i.p. injection with a single dose of CCl4 (20 mg/kg body weight) for 24 h. After hepatic injury induction, renal MDA content was significantly elevated while renal GSH level and the activities of antioxidant enzymes (GR, GPx, GST, catalase, and SOD) were significantly decreased. These results suggest that CCl4 not only induces hepatic injury but also induces kidney dysfunction side by side. Following the treatment with L-arginine, all levels were almost back to normal. Therefore, Larginine administration is found to be an effective protector of both liver and kidney against CCl4-intoxication.
Highlights
L-arginine plays important roles in the metabolism of an organism
MDA level, as a marker of free radical mediated lipid peroxidation injury, was significantly elevated in the kidney homogenate of CCl4-intoxicated mice compared with that of the normal group and it was significantly decreased by pre- or post-treatment with L-arginine to back again around the normal range
And in accordance with others [5], single i.p. dose of CCl4 (20 mg/kg body weight) causes hepatic injury in mice and the administration of L-arginine improved the resistance of hepatic cells to the damaging action of CCl4, indicating the hepatoprotective and hepatocurative activity of
Summary
L-arginine plays important roles in the metabolism of an organism It is the precursor for the synthesis of proteins and other molecules of great biological importance. For young organisms L-arginine is an essential amino acid for optimal growth and development. L-arginine is a semi-essential or conditionally essential amino acid, especially in such conditions as trauma, burn injury, smallbowel resection, and renal failure [1]. L-arginine is synthesized in the proximal tubule of the kidney renal ischemia reperfusion injury as seen after shock, trauma and major vascular surgery, leading to acute tubular necrosis, might reduce Larginine production [3]
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