Abstract
Kidney microsomal Na+, K+-ATPase was studied in rats infected with Trypanosoma congolense. There was an observable loss in affinity of Na+, K+, and ATP for the enzyme in the parasitized animals, as well as a change in the energy of activation (Ea) and transition temperature. The inhibition with vanadate was significantly higher in the parasitized animals compared with that in the control indicating a change in the enzyme's index of physiological efficiency (Vmax/Km). This observation is suggestive of membrane modification in the infected group, thus enhancing permeability to vanadate.In an allied experiment, the level of kidney Na+, K+-ATPase was observed to decline as the parasitemia became massive. This clearly indicates organ damage and the consequent release of quantities of the enzyme into the blood-stream.The relevance of these findings to kidney pathologies during chronic-stage trypanosomiasis is discussed.
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