Abstract
The relationship between kidney damage and hypertension caused by choline deficiency was studied in young male rats. Excretion of a test load of NaCl solution was used as a test of kidney function and it was found that the proportion of Na+ of the test load excreted in 4 hours decreased significantly as choline deficiency progressed. K+ excretion was also depressed by about 15 per cent.Administration of ethyl trichloracetate or α methyl dopa reduced the hypertension in choline deficient rats, with increased rate of Na+ excretion with former treatment and decreased rate of excretion with the latter. Regimes of partial immersion in water had no effect in excretion rate of Na+ but reduced hypertension.Hemicholinium-3 raised blood pressure of choline supplemented rats to levels similar to that of deficient but had no effect either on blood pressure of deficient or Naf excretion in supplemented or deficient rats. Metaraminol inhibited Na+ excretion in both supplemented and deficient rats.
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