Kidney function changes and the risk factors in hospitalized patients aged 80 years and over

Abstract

Objective To investigate the kidney function changes and the risk factors in elderly patients aged 80 years and over. Methods A total of 1054 hospitalized patients aged ≥80 years in our hospital were selected. Serum levels of creatinine, urea, uric acid and urinate were tested. Cockcroft-Gault equation was used to estimate glomerular filtrate rate (GFR). Results The renal function in 87.1% of the patients was reduced. The percentage of patients with 30≤eGFR <60 ml·min-1·1.73 m-2 was 66.2%. The percentage of patients with 15≤eGFR <30 ml·min-1·1.73·m-2 had a gender difference (P<0.05). Serum creatinine level was not an ideal indicator for early renal dysfunction in the elderly, especially in emaciated elderly people. Multivariate logistic regression analysis showed that gender, hypertension, coronary heart disease and hyperuricemia were independent risk factors for the decline of renal function (OR=1.937, 1.602, 1.842, 7.020, respectively, all P<0.05). Conclusions The rate of renal dysfunction is high in very old people. Many risk factors affect renal dysfunction. Key words: Renal insufficiency; Glomerular filtration rate; Risk factors