Kidney Biopsy in HIV: Beyond HIV-Associated Nephropathy

Abstract

A 57-year-old African-American woman with human unodeficiency virus (HIV) infection for 18 years epatitis C presents with an acute decrease in glome ltration rate (GFR) and nephrotic-range proteinuria sup mposed on chronic kidney disease (CKD). She was no ntiretroviral therapy because of nonadherence, and her v oad was 138,000 copies/mL, with a CD4 count of 365 L. he had a remote history of intravenous cocaine and h buse. Serum creatinine levels until 14 months earlier anged from 0.9 to 1.0 mg/dL (80 to 88.4 mol/L; estimated FR [eGFR] using the Modification of Diet in Renal ase Study equation 60 mL/min/1.73 m [ 1 mL/s/1.73 ]). One year before presentation, serum creatinine l as 1.2 mg/dL (106 mol/L; eGFR, 58 mL/min/1.73 m 2