Abstract
In cervical cancer patients it has been reported that there in a significant Ki-67/MIB-1 expression is correlated with survival in cervical cancer patients. However, the prognostic value is still not well understood. In the present meta-analysis the prognostic value of Ki-67/MIB-1 with regard to overall survival (OS) and disease-free survival (DFS) in cervical cancer was investigated. The databases of PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, EMBASE, Science Direct and Wiley Online Library were used to identify appropriate literature. In order to explore the relationship between Ki-67/ MIB-1 and cervical cancer, we have included 13 studies covering 894 patients in the current meta-analysis. The effect of Ki-67/MIB-1 on OS for pooled random effects HR estimate was 1.63 (95%confidence interval (CI) 1.09- 2.45; P<0.05). The pooled HR for DFS was 1.26 (95%CI 0.58-2.73; P>0.05) and the subgroup analysis indicated Ki-67/MIB1 was associated with DFS (HR=3.67, 95%CI 2.65-5.09) in Asians. According to this meta-analysis, Ki-67/MIB-1 has prognostic value for OS in patients suffering from cervical cancer. For better evaluation of the prognostic role of Ki-67/MIB-1 on DFS, studies with larger numbers of patients are needed to validate present findings in the future.
Highlights
Cervical cancer is the fourth most common cancer among women
Lymph node status and pathological features of primary tumor and FIGO stage are thought to be relevant to the prognosis of cervical cancer, considering the fact that the clinical value of Ki-67 for prognostication of cervical cancer is still doubtful, In this meta-analysis it is tried to reveal the impact of Ki-67/MIB-1 on overall survival (OS) and/or disease-free survival (DFS) in cervical cancer
As far as Ki-67/MIB-1 is closely integrated with cell proliferation, it has been known as a tumor marker in cancers due to its close correlation with cell proliferation
Summary
Cervical cancer is the fourth most common cancer among women. Median age of diagnosis is about 52 years, but has a bimodal distribution with picks at 35 to 39 and 60 to 64 years of age. Human papilloma virus infection in cervical cells’ leads to functional changes of host genes and investigating these genes can play an important role in screening and diagnosing cervical cancer (Ghojazadeh et al, 2012a; Ghojazadeh et al, 2012b; Azami-Aghdash et al, 2013; Naghavi-Behzad et al, 2013; Sushma et al, 2014). These functional changes cause changes in cellular cycle which appears through abnormal manifestation of proteins related to this cycle, such as Ki-67 (Ikenberg et al, 2013; Rostamizadeh et al, 2013; Ghojazadeh et al, 2014). Lymph node status and pathological features of primary tumor and FIGO stage are thought to be relevant to the prognosis of cervical cancer, considering the fact that the clinical value of Ki-67 for prognostication of cervical cancer is still doubtful, In this meta-analysis it is tried to reveal the impact of Ki-67/MIB-1 on overall survival (OS) and/or disease-free survival (DFS) in cervical cancer
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