Ki67-PROLIFERATIVE INDEX IN BREAST CANCER AND ITS ASSOCIATION WITH MOLECULAR SUBTYPE, HISTOPATHOLOGICAL GRADE & TYPE - IN A TERTIARY CARE HOSPITAL.

Abstract

Introduction: Carcinoma of breast is the most frequent malignancy in women worldwide and the second most common cause of fatality in patient with cancer. Prognostic factors are essential in breast cancer diagnosis as they allow high risk patient identication, for whom prognosis can be further improved by an adjuvant therapy. Ki67 proliferative index is a potential marker for predicting the responsiveness to chemotherapy. This present study has been designed to analyze the relationship of Ki67 proliferative index with clinico-pathological factors in eighty diagnosed cases of primary breast carcinoma, according to the molecular subtypes. To compare the e Objective: xpression of Ki67 proliferative index with the molecular subtype, histopathological grade and type of breast carcinoma. The study w Material and Methods: as carried out from October 2019 - September 2021 in the Department of Pathology, M.K.C.G Medical College & Hospital, Odisha. 80 cases received for routine histopathological examination were evaluated for histopathological typing and IHC status – ER, PR, Her2neu & Ki67. 46 cases belonged to T2 followed by Result: T3 and T1. 45% cases were Grade III followed by Grade II and Grade I tumors. 74 cases were IDC NOS, 2 cases Lobular, 2 cases Metaplastic, 1 case Medullary and 1 case Mucinous. High Ki67 index seen in 70.37% cases in T3 category followed by T2 (45.65%) and T1(42.86%). Low Ki67 index is associated with Luminal A followed by Luminal B. High Ki67 index is seen in 83.33% of Grade III tumor but none in Grade I tumor. Whereas, high Ki67 index is found in both Her2neu enriched and Triple Negative breast carcinoma. High Ki67 proliferative index Conclusion: was associated with high grade tumor, Her2/neu enriched and Triple negative tumor. However, there was no signicant relation found in association of ER, PR, Her2/neu and Ki67 with the tumor size