Khảo sát tỷ lệ nhiễm Rickettsia và Orientia tsutsugamushi trên bệnh nhân sốt không rõ nguyên nhân tại Hà Giang

Abstract

Rickettsial fever is one of a zoonotic disease which is caused by bacteria genus Rickettsia. The ectoparasites such as ticks, mites, fleas, lice... were demonstrated as the main transmited vectors through host reservoirs are rodents and small animals including mice, squirrels, mink... These is the main cause of Rickettsia infection in human. The prevalence of Rickettsia and Orientia tsutsugamushi in rodents and ectoparasites and patients in Vietnam were reported. However, the data still was not clearly and fully understanding. Ha Giang is one of the important provinces with complex mountainous terrain where there is a high risk of zoonotic diseases. The O. tsutsugamushi was detected in patients collected in Ha Giang province. In current paper, we describe the result for investigating the Rickettsia infection rate as well as the seroprevalence of scrub typhus, Rickettsia typhi and Rickettsia spotted fever group in fever of unknown origin patient collecting in Ha Giang province general Hospital. The ELISA result in 162 patients indicates that seroprevalence of Orientia tsutsugamushi, Rickettsia typhi, and Rickettsia spotted fever group are 33.33%, 8.02%, và 1.85%, respectively. The real-time PCR result shows that the positive rates of Orientia tsutsugamushi, Rickettsia typhi and Rickettsia spotted fever group are 24.69%, 5.63%, và 1.41%, respectively.