Abstract

A simple and mild protocol has been developed for the synthesis of novel steroidal and nonsteroidal thiophene derivatives from β-halo-α,β-unsaturated aldehydes using KF/Al<sub>2</sub>O<sub>3</sub>/PEG-400 as an efficient catalytic system. The β-halo-α,β-unsaturated aldehydes are synthesized from the corresponding ketones using Vilsmeier­ formylation reaction and converted into β-halo-α,β-unsaturated nitriles. The synthetic protocol is subsequently applied to the synthesis of 3-aminothiophene derivatives using β-halo-α,β-unsaturated nitriles.

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