Abstract
Supercritical fluid chromatography (SFC) continues to gain traction with an expanding range of compounds including polar species becoming amenable to this technique. In addition, the use of supercritical fluids to develop new processes and applications continues to form the basis of many research programs. In keeping with these trends, SFC methods to perform supporting measurements can make significant contributions. This review describes the use of on-line SFC directly interfaced to high pressure apparatus to obtain: (1) compound solubility data in supercritical fluid carbon dioxide (SF–CO2), (2) partition coefficient values of compounds distributed between SF-CO2 and aqueous phases, and (3) the use of on-line SFC as a process analytical technology (PAT) tool for reaction progress monitoring. A range of case studies are presented to illustrate the importance and applicability of on-line SFC measurements.
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