Abstract
Endoproteolytic processing of precursor proteins typically at specific pairs of basic amino acids is a key step in the production of bioactive peptides and proteins. The endrproteases involved in this process belong to a new family of Ca2+ -dependent serine proteases related to the yeast Kex2 protease. These include furin, PC2, PC3, PC4, PACE4 and PC6, all of which have been characterized structurally and functionally.
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