Ketone Bodies Mediate Antiseizure Effects.

Jena M Krueger,Douglas R Nordli

doi:10.15844/pedneurbriefs-29-9-2

Jena M Krueger, Douglas R Nordli

Open Access

https://doi.org/10.15844/pedneurbriefs-29-9-2

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Abstract

Investigators from The Barrow Neurological Institute, Creighton University, University of Kentucky and the University of Calgary Faculty of Medicine investigated the effect of ketone bodies and the ketogenic diet on epileptic Kcna1-null mice.

Highlights

The investigators found evidence of protective effects secondary to the ketogenic diet
Treatment with the ketogenic diet restored these deficits to levels seen in the wild type mice
This was re-demonstrated in vitro, as the Kcn1-null mice demonstrated impairment in CA1 hippocampal long term potentiation, which was restored by the ketogenic diet or administration of beta-hydroxybutyrate alone. [1]

Summary

Introduction

The investigators found evidence of protective effects secondary to the ketogenic diet. Kcn1-null mice showed significant difficulties in spatial learning and memory when compared to wild type mice. Treatment with the ketogenic diet restored these deficits to levels seen in the wild type mice.

Results

Conclusion