Abstract
The intracellular pH of the cerebral cortex was studied by the neutral red method in 15 adult rats maintained on ketogenic and control diets for 5-6 weeks.
Highlights
The intracellular pH of the cerebral cortex was studied by the neutral red method in 15 adult rats maintained on ketogenic and control diets for 5-6 weeks
The ILAE classification of seizure types based on electroclinical criteria may be justified for well-defined syndromes, eg benign epilepsy of childhood with centrotemporal spikes, but in the differentiation of frontal and temporal lobe partial epilepsies in adults there is significant clinical/pathological overlap
Equivalent current dipoles (ECDs) of prominent negative sharp waves of rolandic discharges appeared as tangential dipoles in the rolandic region and showed a limited localization compared with other components
Summary
The intracellular pH of the cerebral cortex was studied by the neutral red method in 15 adult rats maintained on ketogenic and control diets for 5-6 weeks. The ILAE classification of seizure types based on electroclinical criteria may be justified for well-defined syndromes, eg benign epilepsy of childhood with centrotemporal spikes, but in the differentiation of frontal and temporal lobe partial epilepsies in adults there is significant clinical/pathological overlap. The antiepileptic effect of the ketogenic diet was probably not mediated by cerebral acidosis or changes in cerebral GABA levels.
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