Ketogenic Diet Decreases Alcohol Intake in Adult Male Mice.

María Del Carmen Blanco-Gandía,María Pascual,Marina Daiana Reguilón,Marta Rodríguez-Arias,Francisco Ródenas-González,Consuelo Guerri,José Miñarro

doi:10.3390/nu13072167

María Del Carmen Blanco-Gandía, María Pascual + Show 5 more

Open Access

https://doi.org/10.3390/nu13072167

Copy DOI

Abstract

The classic ketogenic diet is a diet high in fat, low in carbohydrates, and well-adjusted proteins. The reduction in glucose levels induces changes in the body’s metabolism, since the main energy source happens to be ketone bodies. Recent studies have suggested that nutritional interventions may modulate drug addiction. The present work aimed to study the potential effects of a classic ketogenic diet in modulating alcohol consumption and its rewarding effects. Two groups of adult male mice were employed in this study, one exposed to a standard diet (SD, n = 15) and the other to a ketogenic diet (KD, n = 16). When a ketotic state was stable for 7 days, animals were exposed to the oral self-administration paradigm to evaluate the reinforcing and motivating effects of ethanol. Rt-PCR analyses were performed evaluating dopamine, adenosine, CB1, and Oprm gene expression. Our results showed that animals in a ketotic state displayed an overall decrease in ethanol consumption without changes in their motivation to drink. Gene expression analyses point to several alterations in the dopamine, adenosine, and cannabinoid systems. Our results suggest that nutritional interventions may be a useful complementary tool in treating alcohol-use disorders.

Highlights

Motivation to seek drugs of abuse and highly palatable foods is regulated by the reward system [1]
Regarding changes in bodyweight (Figure 3), the ANOVA revealed a significant effect of the variable diet [F(1,29) = 6.731; p < 0.05], as the ketogenic diet (KD) group presented a higher bodyweight than the SD group (p < 0.05, SD = 38 gr vs. KD = 40 gr)
The results found in the present work revealed that the KD induces an overall decrease in alcohol SA but does not affect the motivation to get the drug

Summary

Introduction

Motivation to seek drugs of abuse and highly palatable foods is regulated by the reward system [1]. It cannot be recommended as a drug-addiction combined therapeutic This metabolic syndrome is avoided when the administration of HFD is intermittent, the accelerated extinction and the blockade of reinstatement is maintained [9]. This contribution opened a new gateway to focus on nutrition as a possible complementary treatment in the field of drug addiction. For this reason, we considered the classic ketogenic diet (KD), a diet still high in fats, to prevent the development of escalation in alcohol consumption

Objectives

Methods

Results

Discussion

Conclusion