Abstract
Investigators from The Department of Comparative Medicine, from Yale School of Medicine report the effect of the ketogenic diet on the T cell immune function in mice exposed to influenza virus.
Highlights
Investigators from The Department of Comparative Medicine, from Yale School of Medicine report the effect of the ketogenic diet on the T cell immune function in mice exposed to influenza virus
This study noted that mice that were fed ketogenic diet had better survival and decreased loss when compared to mice that were not exposed to the ketogenic diet
The investigators sought to analyze the molecular underpinnings of this finding. They performed transcriptome analysis of the mice’s lungs noting that several genes were upregulated in ketogenic diet fed mice; genes associated to γδ T cell responses were increased; including number of cells in lung tissue, and release of cytokines related to this specific cell type
Summary
Investigators from The Department of Comparative Medicine, from Yale School of Medicine report the effect of the ketogenic diet on the T cell immune function in mice exposed to influenza virus. The investigators examined transgenic immunocompetent mice exposed to an intranasal challenge of influenza virus. The mice were fed ketogenic diet prior to the infection.
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