Ketofol Infusion versus Isoflurane as Maintenance of Anesthesia on Hemodynamics in Radical Cystectomy Operation

Abstract

Abstract Background radical cystectomy is a major operation where bleeding from sacral plexus during dissection of the bladder may occurs leading to hemodynamic instability and organ ischemia due to hypo perfusion. So using anesthetic drugs that provide hemodynamic stability will decrease intraoperative and post-operative morbidity and ICU and hospital stay. Objectives The Aim of this study is to compare the effect of anesthetic agent ketofol infusion versus isoflurane inhalation on hemodynamics in maintenance of anesthesia in radical cystectomy operation as a primary outcome and recovery time as a secondary outcome. Methods and material This prospective randomized clinical trial study was conducted in Ain Shams University hospital after approval of the anesthesia department and the local ethics and research committee over 6 months and after obtaining a written informed consent. Sixty patients underwent radical cystectomy were included in the study their ages range between 50 and 70 years old and classified as ASA I and II, III. The patients were randomly divided using computer generated randomization into two groups 30 patients in each (n = 30), Group I received isoflurane inhalation while group K received Ketofol infusion. Results this study demonstrated that maintenance of anesthesia by ketofol infusion provides more hemodynamic stability with maintaining of blood pressure and heart rate rather than isoflurane inhalation. Conclusions We conclude that maintenance of anesthesia with ketofol infusion provides more hemodynamic stability and least intraoperative and postoperative morbidity than isoflurane inhalation in patients undergoing radical cystectomy.