Abstract
Ketofol is a combination of ketamine and propofol. To date, there is significant interest in ketofol as an agent for procedural sedation and analgesia. The combination of propofol and ketamine has several benefits in the terms of hemodynamic stability, absence of respiratory depression, post-operative analgesia and recovery. This combination can be mixed in the same syringe or administered independently in the two separate syringes. It can be administered as a bolus or as a continuous infusion for longer procedures. Ketamine-propofol combinations in the different ratios have been studied before. The optimal mixture and dosing of ketamine and propofol has yet to be determined. This short review will highlight recent clinical supports the therapeutic utility of the combination of ketamine and Propofol.
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