Abstract
Spinal seizures evoked by sudden cooling (SSSC) were used to investigate the anticonvulsant activity of ketamine (KET) injected either intralymphatically (1.1., 5–40 mg/kg) or intrathecally (i.t., 0.5–1.0 μmol/20 μl) using isolated spinal cord-hindleg preparation. KET inhibited the tonic phase and prolonged the clonic phase in a dose-dependent manner. The clonic phase was depressed or totally blocked at KET doses of 80–160 mg/kg, i.l. or 2 μmol/20μl, i.t. This depression was not prevented by i.t. administration of concanavalin A. The latency of onset of seizures was also increased by KET. KET abolishes the tonic-extensor phase of SSSC in which activation of N-methyl-D-aspartate-receptors may play a role.
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