Abstract
The Journal of Antibiotics (2009) 62, 221–224; doi:10.1038/ja.2009.10; published online 6 March 2009Keywords: kerriamycin B; SUMO-1; SUMO-activating enzyme (E1)Post-translational conjugation of small ubiquitin-related modifierprotein (SUMO) to protein substrates (SUMOylation) hasbeen revealed as one of the major post-translational regulatorysystems in animals and other eukaryotes. SUMO conjugation iscatalyzed by a multi-step enzymatic reaction cascade similar toubiquitinylation.
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