Abstract
Nuclear pore complexes (NPCs) span the nuclear envelope (NE) and mediate nucleocytoplasmic transport. In metazoan oocytes and early embryos, NPCs are also parts of a sub-compartment of the endoplasmatic reticulum (ER), termed annulate lamellae (AL). We could demonstrate that AL insert into the NE in Drosophila blastoderm embryos. We suggest a topological model in which NE openings are crucial for AL uptake without compromising the permeability barrier of the NE. This mode of pore insertion is developmentally regulated and operates before the induction of zygotic transcription.
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