Abstract

Keratosis lichenoides chronica: A case report and focused overview of the literature

Highlights

  • Keratosis lichenoides chronica (KLC) is an inflammatory skin disorder, characterised by diffuse, lichenoid hyperkeratotic papules arranged in an either linear or reticular fashion, erythematosquamous plaques and seborrheic-like dermatitis on the face.[1]

  • Histopathological findings typically include hyperkeratosis with focal parakeratosis, irregular acanthosis admixed with areas of atrophy, vacuolar degeneration of the basal layer and mixed inflammatory lichenoid infiltrates in the upper dermis.[3]

  • In response to a variety of stimuli, NLRP1 activates caspase-1 leading to increased production of interleukin (IL)-1 and IL-18

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Summary

Introduction

Keratosis lichenoides chronica (KLC) is an inflammatory skin disorder, characterised by diffuse, lichenoid hyperkeratotic papules arranged in an either linear or reticular fashion, erythematosquamous plaques and seborrheic-like dermatitis on the face.[1]. Conflicts of interest: All authors declare no conflicts of interest. Cutaneous appendages can be involved as well, with onychodystrophy or alopecia.[2] Histopathological findings typically include hyperkeratosis with focal parakeratosis, irregular acanthosis admixed with areas of atrophy, vacuolar degeneration of the basal layer and mixed inflammatory lichenoid infiltrates in the upper dermis (often around infundibula and acrosyringia).[3] Further complicating its diagnosis, several clinicopathological variants of KLC have been described, including vascular, purpuric, lupus-like, porokeratotic associated to amyloidosis and generalised forms (Table S2).

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