Keratoprosthesis – A Review Article

Abstract

Keratoprosthesis (Kpro) evolution over the years has been remarkable from initially rejected due to devastating complication to the present with development of multiple biocompatible materials and acceptable designs. Its indications have expanded beyond recurrent immunologic rejection to include other conditions such as chemical injury and other causes of bilateral limbal stem cell deficiency, extensive corneal neovascularization, neurotrophic corneas, and hypotony. Since then, it is accepted worldwide by many cornea specialists and now has become a standard procedure. Improvement in pre-operative, intra-operative, and post-operative management has resulted in favorable outcomes with reduction in complications. However, sight-threatening complications are even now reported in auto-immune and cicatrizing conditions, which requires prompt management and frequent follow-ups. Researchers in the field have been recently working on improving the design of the currently available devices by introducing the use of new materials that are more biocompatible with the eye. This review article gives an update on recent research in the field, indications, types, and comprehensive detail on outcomes with Kpro.