Abstract
Keratocyst of the buccal mucosa is rare, with approximately 20 cases reported to date. A 58-year-old male patient was referred for evaluation of an exuberant swelling of the midface of 2 years' duration. Intraoral examination revealed an asymptomatic tender swelling in the right buccal mucosa, with a smooth surface and normal coloration, measuring 5 cm. Extraosseous location was confirmed by panoramic radiographic examination. Aspiration revealed a yellowish creamy material. Incisional biopsy was performed, and multiple small soft tissue fragments were microscopically evaluated. There was a cyst lined with 6 cell layers composed of columnar palisading basal cells and a corrugated parakeratinizing surface. The capsule was composed of fibrous connective tissue with blood vessels, areas of hemorrhage, nerve bundles, and absence of pilosebaceous units. The final diagnosis was of keratocyst of the buccal mucosa. The odontogenic origin of keratocyst from buccal mucosa is still debatable.
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