Abstract
Hibiscus cannabinus (kenaf) seed oil is a rich source of bioactive phytochemicals with high anti-oxidative and cancer chemopreventive properties. However, the seeds are disposed aswaste material during the harvesting or processing of kenaf. Preliminary study revealed that kenaf seed oil from supercritical carbon dioxide fluid extraction (SFE) induced apoptosis in WEHI-3B leukemia cells. Thus, this study was carried out to investigate the effects of kenaf seed oil from SFE on WEHI-3B cells in vivo. Acute toxicity study revealed that kenaf seed oil is practically non-toxic by oral route. Treatment with kenaf seed oil increased the population of T cells, but decreased the populations of immature monocytes and granulocytes in the peripheral blood of WEHI-3B/BALB/c mice. The weights of the spleen and liver of WEHI-3B/BALB/c mice decreased after the treatment with kenaf seed oil. Moreover, infiltration of leukemic cells into the splenic red pulp reduced after the treatment. In conclusion, kenaf seed oil reduced the severity of leukemia in WEHI-3B/BALB/c mice. These results provide information to industrialists and farmers to fully utilize and develop kenaf seed oil as a novel bio-health product. Key words: Hibiscus cannabinus (kenaf), oil, supercritical carbon dioxide fluid extraction, WEHI-3B; BALB/c mice, leukemia.
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