Kelainan Neurologi akibat Kondisi Hiperkoagulasi pada Pasien Coronavirus Disease-19

Abstract

Coagulopathy is one of the clinical manifestations of severe Coronavirus Disease of 2019 (Covid-19), and causes a poor prognosis of the disease. The clinical manifestations of Covid-19 have a broad spectrum, namely asymptomatic, non-specific mild symptoms (fever, dry cough, diarrhea), mild pneumonia, severe pneumonia (dyspnea, tachypnea, and impaired gas exchange), acute respiratory distress syndrome (Acute Respiratory Syndrome). Distress Syndrome/ARDS), Disseminated Intravascular Coagulation (DIC), sepsis, and multiple multiorgan dysfunction syndrome. Covid-19 patients experience a severe inflammatory state that causes an increase in the activation of the coagulation cascade, an increase in thrombin, and a hypercoagulable state, thereby increasing the risk of thrombosis in the blood vessels of the brain and spinal cord. Conditions such as old age, smoking, hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, and malignancy can increase a patient's risk of experiencing a more severe degree of COVID-19 and higher mortality. The presence of Covid-19 complications such as thrombosis can affect the patient's prognosis and mortality