Abstract
While much knowledge about glycans has accumulated, most of the primary data for both experimental and bioinformatics analyses are information on glycan structures and glycan-related genes. Therefore, it is necessary to aggregate all these chemical and genomic information together in an effort to predict complex cellular processes and to understand organism behaviors at a higher level. Following this perspective, we have been developing KEGG (Kyoto Encyclopedia of Genes and Genomes) (Kanehisa et al. 2008) to include three basic glycan resources: (1) GLYCAN, a database of glycan structures; (2) the glycosyltransferase and the glycosidase reaction library; and (3) glycanrelated pathways (Hashimoto et al. 2006). KEGG also includes three useful tools: (4) the Composite Structure Map (CSM), a map illustrating all possible variations in glycan structures within organisms; (5) KegDraw, an intuitive drawing tool for chemical structures; and (6) KCaM, a glycan search and alignment tool (Aoki et al. 2004). All resources are available at KEGG (http://www.genome.jp/kegg/glycan/).
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