Abstract
Innate Lymphoid Cells A number of bodily functions, from feeding to sleeping, are regulated by circadian clocks. Teng et al. and Wang et al. report that expression of several genes in intestinal group 3 innate lymphoid cells (ILC3s) in mice is synchronized to the time of day. To probe the role of clock proteins in regulating ILC3 functions, the two groups studied mice lacking distinct clock proteins, BMAL1 and REVERBα. The loss of these clock proteins resulted in decrease in the number of intestinal ILC3s, but these cells produced higher levels of certain cytokines. How clock proteins fit within the larger network of transcription factors regulating development and gene expression in ILC3s remains to be seen. Sci. Immunol. 4 , eaax1215, eaay7501 (2019).
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