Abstract
A recent report in a peer-reviewed UK journal outlines five cases of optic neuropathy thought to be related to long-term treatment with selective serotonin reuptake inhibitors (SSRIs).1 These five were identified over a 2-year period within an island population of 140 000. Each case was assessed using the Naranjo algorithm to indicate likelihood of adverse drug reaction (ADR).2 The Naranjo scores indicated possible ADR in four cases and probable ADR in one case. All five cases presented with visual loss from suspected ischaemic optic neuropathy (ION) and were all extensively investigated for any other possible underlying cause. A ‘non-arteritic’ ischaemic origin was suspected in all cases. Toxicity was felt to be unlikely since three cases were of sudden onset and two cases were unilateral. Two cases …
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