Kearns-Sayre Syndrome: A Rare Mitochondrial Disorder

Ham Nazmul Ahasan,Homayra Tahseen Hossain,Ishrat Binte Reza,Khaddoker Morshedul Alam,Maksudul Majumder,Md Abul Kashem Khandaker,Quazi Tarikul Islam,Tajnuva Jabeen

doi:10.3329/jom.v19i1.34847

Ham Nazmul Ahasan, Homayra Tahseen Hossain + Show 6 more

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https://doi.org/10.3329/jom.v19i1.34847

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Abstract

Mitochondrial disease, once thought to be a rare clinical entity, is now recognized as an important cause of a wide range of neurologic, muscle, cardiac and endocrine disorders. Kearns Sayre syndrome is a rare mitochondrial disease, involving deletion of mitochondrial DNA. This syndrome ischaracterized by progressive external ophthalmoplegia (PEO), retinitis pigmentosa and an onset before the age of 20 years. First case was reported in 1958. We are reporting a case with chronic progressive external ophthalmoplegia, bilateral partial ptosis with onset at 10 years of age. He also had features of myopathy and neuropathy without any fatigable weakness. Our diagnosis is mostly based on clinical background and by exclusion of other common disorders, as definitive diagnostic investigation genetic testing due to unavailability so was not done.J MEDICINE Jan 2018; 19 (1) : 66-69

Highlights

Kearns-Sayre syndrome (KSS) is a variety of mitochondrial disease characterized by progressive external ophthalmoplegia (PEO), pigmentary retinitis and an onset before the age of 20 years
Combination of ptosis, ophthalmoplegia, features of both myopathy and neuropathy with absence of fatigability in a young patient pointed our diagnosis towards mitochondrial disease
Many affected individuals display a cluster of clinical features that fall into a discrete clinical syndrome, such as ‘mitochondrial encephalopathy with lactic acidosis and stroke- like episodes’ (MELAS)

Summary

Introduction

Introduction: Kearns-Sayre syndrome (KSS) is a variety of mitochondrial disease characterized by progressive external ophthalmoplegia (PEO), pigmentary retinitis and an onset before the age of 20 years. 1. Professor, Medicine, Popular Medical College Hospital, Dhaka 2. Associate Professor, Medicine, Popular Medical College Hospital, Dhaka

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