Abstract
channel (BK-KCa, KCa1.1,maxiK) is one of the important ion channel mechanisms in controllingneuroexcitability and neurotransmitter release. In the sensory nervesystem, KCa1.1 plays important roles in mediating afferent reflex, neu-ropathic pain, and other sensory functions. KCa1.1 widely expresses ineither somatic or visceral afferent neuronsincluding baroreceptor neu-rons (BRNs), which are composed of a pore-forming α-subunit andmodulatory β-subunits. Among β-subunits, β4 expressed abundantlyin CNS and plays key roles in Ca
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