Abstract
The attenuated KB/VT strain of Getah virus was established from the parental 2078 strain by the serial passages and plaque clonings in Vero cell cultures at the low temperature of 30°C.The KB/VT strain induced no clinical signs in suckling mice by intracerebral inoculation with the virus. The KB/VT strain formed clear plaques on cultures of hamster lung cell line (HAL) as did other virulent Getah virus strains, but the plaque size was obviously small and distinguishable from that of the parental 2078 strain. This character was stable even after 5 consecutive passages of the KB/VT strain in HAL cell cultures at 37°C. The KB/VT strain showed antigenicity similar to these of the other virulent strains by cross neutralization test. All these findings suggested that the KB/VT strain might have so attenuated as to be available as a candidate strain for a live virus vaccine against Getah virus infection in swine.
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