Abstract
Purpose: This study aimed to investigate the effect of glide path preparation before shaping with reciprocating single-file, rotary single-file and multiple-file systems on the debris extrusion from the apical, and on the root canal transportation. 
 Materials and Methods: One hundred twenty curved mesial root canals of mandibular first molars were randomly distributed to six groups (n=20). The root canals were prepared with Reciproc in Group R, OneShape in Group OS, and ProTaper Next in Group PN. In the last three groups (RG, OSG and PNG), a glide path was created before the shaping instruments used in the first 3 groups. The pre- and post-preparation weight were measured by using a 10-5 microbalance. Pre- and post-preparation of the root canals were scanned by using cone-beam computed tomography (CBCT). 
 Results: The debris extrusion in RG and OSG was significantly higher than R and OS, respectively. However, no significant differences were found between PN and PNG. Considering the root canal transportation, RG showed lower than R for 5 mm and 7 mm levels and the OSG group showed lower than OS for all levels. Creating a glide path significantly increased the shaping time for OS and PN groups. 
 Conclusion: In advance of shaping with a single-file system in curved canals, creating a glide path preserves canal anatomy. However, it may lead to increase apical debris extrusion.
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