Abstract
Four ent-kaurene diterpenes were isolated from the leaves of Laetia thamnia L.: ent-kaur-16-en-19-oic acid ( 1a), ent−3β-hydroxykaur-16-ene ( 2), ent-kaur-16-en-3α,19-diol ( 3a), and ent-17-hydroxykaur-15-en-19-oic acid ( 4). The methyl ester ( 1b) of compound 1a and the acetate diester ( 3b) of compound 3a were prepared, and all compounds were evaluated for cytotoxicity against human prostate (22Rv1, LNCaP), colon (HT29, HCT116, SW480, SW620), and breast (MCF-7) tumor cells at concentrations ranging from 6 to 50 μg/mL. The kaurenes showed activity in all cell lines tested, with the prostate cells demonstrating the most sensitivity as follows: 22 Rv1 cells towards 1a (IC 50 5.03 μg/mL) and 1b (IC 50 6.81 μg/mL), and LNCaP towards 2 (IC 50 12.83 μg/mL) and 4 (IC 50 17.63 μg/mL).
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